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| Reactivity:? | Human???? |
| Applications:? | FCM???? |
| Host Species:? | Mouse???? |
| Isotype:? | Mouse IgG2a, κ???? |
| Clonality:? | Monoclonal???? |
| Conjugation:? | Unconjugated???? |
| Synonyms:? | T-cell surface glycoprotein CD8 alpha chain,CD8A,T-lymphocyte differentiation antigen T8/Leu-2,MAL |
| Background:? | CD8a is a 32-34 kD type I glycoprotein. It forms a homodimer (CD8a/a) or heterodimer (CD8a/b) with CD8b. CD8, also known as T8 and Leu2, is a member of the immunoglobulin superfamily found on the majority of thymocytes, a subset of peripheral blood T cells, and NK cells (which express almost exclusively CD8a homodimers). CD8 acts as a co-receptor with MHC class I-restricted T cell receptors in antigen recognition and T cell activation and has been shown to play a role in thymic differentiation. Two domains in CD8a are important for function: the extracellular IgSF domain binds the α3 domain of MHC class I and the cytoplasmic CXCP motif binds the tyrosine kinase p56 Lck. |
| Gene ID:? | 925 |
| SwissProt:? | P01732 |
| Concentration:? | 0.5 mg/mL???? |
| Buffer:? | PBS with 0.05% Proclin300 |
| Storage:? | Store at 2~8°C. Do not freeze. |
| Documents:? | 請聯系客服索取產品說明書 |
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